Category: Biography

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  • Leonardo da Vinci: A Genius in the Wrong Millennium

    Leonardo da Vinci: A Genius in the Wrong Millennium

    Leonardo da Vinci was more than just a gifted painter. He was also a brilliant scientist, architect, engineer, astronomer, inventor, and an all-around genius. Despite his famous artistic creations like the Mona Lisa or the Last Supper, few of his scientific discoveries, apart from his notes, have been preserved for future generations. He designed self-propelled carts and aircraft, but he began to have these visions too early. Most of his innovative ideas and unfinished paintings remained in his notebooks, causing even this knowledgeable genius to feel like a failure.

    Around 500 years ago, on May 2, 1519, Leonardo di ser Piero da Vinci, one of the greatest polymaths in human history, passed away. In addition to creating unique works of art, he was also a scientific trailblazer. He envisioned ideal cityscapes, flying machines, “infinity machines,” a technique for measuring the distance between stars, and human anatomy. Many of his accomplishments remain remarkable and distinctive to this day.

    Portrait of Leonardo da Vinci, drawn by his pupil Francesco Menzi.
    Portrait of Leonardo da Vinci, drawn by his pupil Francesco Menzi.

    Nonetheless, his output reflects the labor of a brilliant mind that is still actively seeking new competitors today. Leonardo da Vinci, the quintessential Renaissance man, conceived utopian ideas that are still mystifying today.

    Can one person really be so far ahead of their time? It’s difficult to comprehend how he could have foreseen concepts that would take centuries to be realized. The idea of using rotors to generate lift, which was originally conceived by da Vinci 500 years ago but was rediscovered and put into practice only a century ago with the introduction of diving ships.

    In 1452, Leonardo da Vinci was born in the town of Anchiano in Tuscany (now Italy), not far from the town of Vinci from which he took his surname.

    According to da Vinci himself, his art served as a means to an end: the pursuit of knowledge. “If you disdain painting, which is merely an imitator of all the works revealed by nature,” da Vinci declared, “you will surely disdain a precise investigation that examines all the textures of forms with philosophical and subtle speculation.” Da Vinci’s work elevated science above art, and the universe he imagined is still full of surprises.

    Learning the Ropes at the Feet of the Renaissance

    One Young Man’s Life in Tuscany

    Anchiano, a little town close to Vinci, was his home for the first five years of his childhood. Today, the small town of Anchiano in northern Tuscany still retains its original appearance from the time when Leonardo da Vinci resided there.

    It comprises a handful of farmhouses constructed from light-colored fieldstone, perched on a hill overlooking pine forests, olive orchards, and cypress forests, and surrounded by gently rolling fields. Da Vinci, the preeminent genius of his era, was born in this Italian town on April 15, 1452, around 3 a.m.

    Da Vinci was born into the Renaissance, an era of change and rejuvenation. This epoch, during which intellectuals and artists revived the ideals of Greek and Roman antiquity, is often regarded by historians as marking the end of the “dark” Middle Ages.

    In libraries, long-lost knowledge was rediscovered, sparking a renewed thirst for knowledge. Da Vinci would ultimately be celebrated as one of the greatest minds in human history.

    Leonardo Da Vinci’s Family

    The house in Anchiano where Leonardo da Vinci was born.
    The house in Anchiano where Leonardo da Vinci was born. Image credit: Roland Arhelger

    His mother was Caterina, a maid, and his father was Ser Piero da Vinci, a prominent notary from Florence. Leonardo was born into a tumultuous family at the time. While Ser Piero always acknowledged Leonardo as his son, he initially placed him in the care of a peasant family.

    When Leonardo was five years old, Ser Piero moved in with his new wife, a 16-year-old-girl Albiera Amadori, whom he had previously married six months after Leonardo’s birth.

    Ser Piero’s family resided in Vinci, and over time, Leonardo grew to consider Florence his “home,” even adopting the city’s name and referring to himself as “Leonardo the Florentine” but the name “Leonardo da Vinci stuck.”

    Although he attended school sporadically for a few years, he gained enough literacy skills to read and write in this environment. It wasn’t until later in life that he fully grasped the four fundamental arithmetic operations.

    Despite this, Leonardo was naturally curious and explored the countryside freely with his uncle Francesco or on his own, learning about the local flora and fauna, and investigating rivers, caves, and other hidden locations.

    Having Trained with Master Verrocchio

    Leonardo was unable to attend university due to his low social status. However, his father, Ser Piero, recognized his prodigious creative talent and arranged for him to apprentice with the Florentine master Andrea del Verrocchio.

    While not a particularly innovative thinker, Verrocchio was a skilled artisan who worked in a variety of mediums, including jewelry, painting, sculpture, music, and woodcarving. He oversaw one of Florence’s most diverse workshops, and it was here that Leonardo began his artistic studies at the age of 14.

    In keeping with the ethos of the emerging Renaissance, which harkened back to the traditions of antiquity and placed the creative human being at the center of knowledge, Leonardo developed a wide range of artistic abilities that reflected his restless and inquisitive temperament.

    He painted, sketched, sculpted, cast, and worked in bronze. He also tailored clothing and helped plan magnificent feasts for the Tuscan courts.

    After seeing the emotional depth of Leonardo’s art, Verrocchio recognized the limitations of his own abilities. When Leonardo painted an angel for Verrocchio’s piece “The Baptism of Christ” and the young apprentice’s work outshone his teacher’s, Verrocchio supposedly put down his brush forever. At least, that is what the folklore maintains.

    Leonardo's career as a painter took off with the completion of the "Mona Lisa" in 1503–05. This is one of his few completed works of art.
    Leonardo’s career as a painter took off with the completion of the “Mona Lisa” in 1503–05. This is one of his few completed works of art.

    Leonardo’s exceptional attention to detail is evident in his artistic pursuits, particularly in painting. This can be seen in almost all of his works of art, including his most famous piece, the “Mona Lisa.”

    The painting not only captures the woman’s facial expression with groundbreaking precision but also the entire composition.

    Countless intricate elements in the background of the painting are almost imperceptible due to Leonardo’s hazy “sfumato” technique.

    Self-Sufficiency Dawns on Leonardo

    At the age of 20, Leonardo was admitted to Florence’s the Guild of Saint Luke, a guild for painters. He had achieved master status and was now able to open his own shop and manage his own accounts.

    Once he moved to Florence, he quickly befriended other painters such as Sandro Botticelli and Pietro Perugino and began networking with other creatives in the area.

    He established his own studio in 1476, but he struggled to attract clients. The Medici family ignored him because he wasn’t interested in politics. When he was falsely accused of homosexuality and threatened with public ostracism and work restrictions, he decided to seek out a new patron.

    Da Vinci wrote a “letter of application” to Ludovico Sforza, who would later become the Duke of Milan. In the letter, Leonardo highlighted his expertise in the production of military hardware, including his skills in constructing invincible chariots, bombards, mortars, missiles, and his expertise in ship defense and attack.

    Although da Vinci briefly mentioned his other talents, like painting and sculpting, Sforza was confident that his inventions could meet all of the military’s requirements. As a result, Leonardo relocated from Florence to Milan in approximately 1482.

    Art Becomes Science

    Insightful Paintings

    Leonardo da Vinci's research on water in 1513.
    Leonardo da Vinci’s research on water in 1513. Credit: Royal Library, Windsor

    During his 20-year stay in Milan, Leonardo produced his most remarkable body of work. He managed to gain a foothold at the court of the Sforza family, the Milanese royalty.

    Duke Ludovico Sforza, who was also known as “il Moro” or “the Dark One,” provided Leonardo with the opportunity to pursue his diverse interests beyond art by appointing him as a castle builder, military expert, and later, master of ceremonies.

    Leonardo acquired knowledge in various fields such as geometry, statics, hydraulics, geology, optics, anatomy, zoology, botany, cartography, shipbuilding, and architecture.

    In the city of Lombardy, Milan, Leonardo began documenting his ideas in notebooks, with meticulous attention to the visual presentation of his work, using mirror writing with his left hand.

    Leonardo da Vinci's sketch for a water wheel, 1480–82
    Leonardo da Vinci’s sketch for a water wheel, 1480–82

    By the end of his life, the notebooks or codices, as they were called, had grown to almost 13,000 pages, with the breadth of knowledge comparable to a dictionary.

    Although only around 7,000 pages have survived the centuries, they are still considered to be Leonardo da Vinci’s most significant contribution.

    In terms of technology, Leonardo’s ideas found in his codices were centuries ahead of their time. He devised designs for everything from city layouts and hydraulic pumps to carts, machine guns, cranes, wheels, diving bells, and flying machines. For instance, Da Vinci’s diving suit was not only possible, but also practical.

    Da Vinci's drawings of scuba gear, from the Codex Arundel.
    Da Vinci’s drawings of scuba gear, from the Codex Arundel.

    He also kept personal notes on the energy of nature and covered various topics such as the water cycle, continental drift, and human reproduction.

    Alongside anatomical drawings, maps, and illustrations of fossils or plants, there were shopping lists, book recommendations, and philosophical discussions on the nature of science.

    The codices contained guidelines for perspective drawing, advancements in foundry techniques, calculations, dates, instructions for hydraulic tests, and methods for measuring air pressure, gravity, and water flow, accompanied by images of fluid dynamics and traction.

    For Leonardo, creation was a natural extension of his creative process. Painting was a means to an end, a tool he used to aid his understanding. To him, the two fields were interwoven. In one passage, he explored visual perception, focusing so intently on the “most critical instruments” that he delved into the anatomy of the eye.

    Leonardo da Vinci's equine research in 1490.
    Leonardo da Vinci’s equine research in 1490. Credit: Royal Library, Windsor.

    From there, he delved into the mechanics of vision, debated the origins of light, and ultimately considered the stars, which served as a colossal mirror.

    Next, he investigated water, studying its movements and drawing parallels between the waves on a lake, sound, and the sun’s rays. His experimentation with light and shadow in the darkroom ultimately brought da Vinci back to his painting pursuits.

    Leonardo is a consummate observer, sketcher, and innovator. He sees himself as an analytical and critical thinker, capable not only of replicating but also improving upon the original. By skillfully documenting his ideas, Leonardo laid the foundation for contemporary observable and abstract scientific inquiry.

    A Matter of Perspective

    da Vinci's "The Last Supper," 1495–98.
    da Vinci’s “The Last Supper,” 1495–98. Credit: W. Commons.

    The number of paintings attributed to Leonardo da Vinci during his lifetime is approximately 30. However, it is his works of art, particularly the “Mona Lisa” and “The Last Supper,” that solidify his place in the history of art and make him one of the most renowned painters worldwide.

    Even in his artistic creations, Leonardo’s analytical nature is apparent. He makes decisions regarding the painting’s composition, color scheme, and layout, while also considering lighting, placement of figures, and any shadow effects.

    The early sketches of what is commonly regarded as his masterpiece, “The Last Supper,” can be found in geometrical treatises detailing how to construct an octagon from a circle.

    An Important Task for the Monastery

    The commission for “The Last Supper” came from Ludovico Sforza, who needed a painting to decorate the refectory, the dining hall for the monks at the Santa Maria delle Grazie monastery in Milan. In 1495, Leonardo began work on a fresco that would eventually measure approximately 30 feet (9 m) in length and over 13 feet (4 m) in height.

    He envisioned the painting as an extension of the dining room, with Jesus and his followers seated at a table similar to the one used by the monks. He employed a dramatic perspective, which enhanced the sense of depth and complemented the refectory’s natural lighting.

    Finally, he arranged the figures: All lines leading into the image converge at Jesus’ head, which serves as the painting’s vanishing point. By grouping each disciple in a trio, he departed from the conventional pattern of showing all 12 apostles on a single image plane.

    Judas’ defensive posture as he fumbled with the bag containing the thirty pieces of silver was all the evidence Leonardo needed to portray him negatively, placing him in the shadow of Jesus’ preferred disciple, John.

    Irregular Genius

    Leonardo Da Vinci's Jesus with faded colors and peeling plaster.
    Leonardo Da Vinci’s Jesus with faded colors and peeling plaster. Credit: Monastery of Santa Maria delle Grazie, Milan.

    However, the “Last Supper,” which was supposed to lead to a revolution in pictorial composition, once again brought to light a trait of the universal genius that had already strained the patience of his clients several times. Because Leonardo was unreliable and infinitely slow.

    Sforza, who commissioned the piece, had received complaints from the monks who lived there. For nearly a year, the monks had been waiting for da Vinci to finish their masterpiece, and all that was left was Judas’ head.

    When questioned by the duke, Leonardo said that he actually spent at least two hours every day working on the project.

    As the story goes, da Vinci spent almost a year frequenting a seedy doss house and rubbing elbows with the lowlife there, all for the sake of finding the perfect wicked visage to match Judas.

    The physiognomic drawings of Leonardo da Vinci on male heads.
    The physiognomic drawings of Leonardo da Vinci on male heads.

    Leonardo placed a high value on physiognomic research, but his dedication to the field was exceptional for the period. He looked for face and hand models, classified noses into 10 different kinds from the side and 12 from the front and kept an eye out for body language and expressions of emotion.

    But his inconsistency was problematic, as was the time he spent sketching and then painting his ideas. Leonardo was often sidetracked by anything that didn’t need his full attention. Ironically enough, his contemporaries were critical of his lack of interest in painting.

    Instead of meeting deadlines, Leonardo often experimented with unusual methods, such as inflating sheep intestines into room size using bellows, giving tamed lizards wings created from the skin of other insects, creating lifelike wax dolls, or studying the many types of grapes in his vineyard.

    When Leonardo Destroyed the Last Supper

    During the Renaissance, artists used the quick fresco method, applying pigments to wet plaster for rapid execution before it dried, bonding the pigments as it cured. Skilled hands were needed to capture the image before the plaster dried too much to accept the pigments effectively. Leonardo da Vinci and other artists commonly employed this technique.

    To destroy “The Last Supper,” all it took was one experiment: Leonardo’s meticulousness and high standards for perfection were incompatible with the quick fresco method of the time.

    Painting “al fresco” involved working directly on wet plaster. A fast painter with good decision-making skills was essential for this technique. For the sake of saving time reworking his mistakes, Leonardo attempted the tempera on plaster technique and thus, came up with a new method.

    However, this decision had terrible consequences. Paint began to peel and fell off in a continuous shower of flakes after just a few years. His Last Supper has been the subject of a conservation and restoration effort that has lasted generations.

    Until it undergoes comprehensive repair, Leonardo’s “Last Supper” will remain a “maintenance case” for the foreseeable future.

    Da Vinci’s Anatomical Studies

    Neither the study of public figures nor the finger exercises for portraits satisfied Leonardo’s insatiable curiosity about the human form. For him, studying models was essential even in the late 15th century so that his depictions of people would often be anatomically accurate and convey the right emotions.

    On the other hand, he went above and beyond when he was in his late 50s and back in Milan at the French governor of Milan Charles II d’Amboise’s request in 1506. The Council of Florence requested that Leonardo return quickly to complete The Battle of Anghiari, but the king of France, Louis XII, granted him permission to leave in order to commission portraits from him.

    When it comes to human subjects, Leonardo was the first artist to ever do such an analysis. He dissected muscles and bones with the precision of a sculptor and the sight of a painter.

    Dissected 35 Cadavers in a Year

    Leonardo da Vinci's anatomical studies of the shoulder.
    Leonardo da Vinci’s anatomical studies of the shoulder. Credit: Royal Library, Windsor.

    In 1510, despite a papal prohibition, Leonardo dissected over 35 human cadavers by himself. At first, he was just curious about the body’s structure and mechanical processes, but as he dove further into his research, he grew more intrigued by physiological and medical concerns.

    The small quantity of recently deceased corpses and their quick deterioration made the task more challenging. However, Leonardo was able to examine the bodies of people of all ages, and he quickly discovered significant disparities between them.

    He dissected a dead man in Milan’s Santa Maria Novella Hospital in search of the elderly man’s cause of death. A “parchment-like, shrunken, and deformed artery” was the first example of arteriosclerosis to be described in medical literature, according to his findings.

    After some time, Leonardo developed a genuine fascination with the inner workings of the human body, particularly the nervous system, cardiovascular system, digestive system, respiratory system, and musculoskeletal system.

    The interdependencies of the body’s parts were of particular interest to him. By writing a dissertation titled “On the Structure of the Human Body,” he hoped to shed light on “the beginning of their being” for his fellow humans.

    Leonardo usually carried a pen and pencil for just such an occasion. He dismantled the bodies carefully, protecting any vulnerable areas, and filling them with liquefied wax. He produced several drawings as a record of his study, attempted plastic portrayal from different vantage points, and experimented with different lighting conditions.

    At Odds with the Antiquity

    Da Vinci's study of a fetus.
    Da Vinci’s study of a fetus. Royal Library, Windsor.

    It was not always easy for Leonardo to put aside his conventional wisdom and put his whole faith in what he saw. While there was much that eluded him, he did his best to square his findings with the presumptions of antiquity and provide proof of their veracity, even if he could not explain it.

    Da Vinci’s inaccurate depictions of the male and female reproductive systems included his belief that the penis was related to the testicles, lungs, and brain. Although sperm was essential for reproduction, a spiritual substance was also required. According to him, this material traveled down the spinal cord to the penis.

    However, sometimes Leonardo was right. Though he never dissected a pregnant woman, Leonardo da Vinci was widely regarded as having created the first depiction of a human fetus in gestation. According to legend, he learned everything he knew about embryos from a pregnant cow.

    But in the end, he also managed to debunk some of the traditional beliefs. Vitruvius (c. 80 BC–15 BC), a Roman architect, famously studied proportions and established the dimensions of a perfect body and Leonardo da Vinci drew inspiration for his Vitruvian Man from his ideas.

    Leonardo took his own measurements to accurately record the stature of young men and to address flaws in Vitruvius’ antique model, such as the proportionally huge size of the feet.

    Medically Insignificant but Artistically Valuable

    Vitruvian Man.
    Vitruvian Man.

    As far as we know, Leonardo’s anatomical book never saw the light of day. What he really wanted to do was explain what a soul was. Yet, the cardiovascular system, the respiratory system, and the vocal apparatus, the last of his research areas made him resignedly gave up on this pursue.

    Awed by the intricacy of the universe, he had yet to solve the riddle of existence or make sense of the discoveries that he had made. His findings were pretty much useless according to the medical community of his time.

    But what remains from his exploration of the human body are over 200 pages of drawings that possess remarkable scientific accuracy and artistic elegance, previously unseen by the world. His drawings were used as a kind of illustration for millennia before they were refined to become the gold standard of anatomical depiction.

    Cars, Bicycles, and Perpetual Motion

    “Mechanics is the Paradise of the Mathematical Sciences”

    Leonardo was interested in the transfer of power his whole life. Specifically, he was thinking about how force could be multiplied and how back-and-forth motion could be converted into rotation.

    Over the years, he came up with a great many innovations thanks to his fascination with weight, velocity, and leverage. As an engineer, Leonardo cared more about the usefulness of his inventions and how they might improve the lives of artisans than anything else.

    In Search of Laws

    Da Vinci's design for a car, a self-propelled cart.
    Da Vinci’s design for a car, a self-propelled cart.

    He investigated the possibility of universal physical rules and lays the groundwork for the parallelogram of forces, which won’t be fully defined until the 16th century. His findings included the dependence of friction on pressure and surface structure and the principles of leverage. Also, he created a lot of fundamental mechanical components.

    Before developing the components for machines to handle complicated mechanical issues, he sketched screws, springs, pulleys, winches, and gears. Ball bearings, for example, were not devised for another 500 years; disc connections, which resembled modern clutches, were also included in his desings; as were intricate link chains, which he did not find any use.

    He did not create the first gears, ratchets, levers, or pulleys, but he did discover some novel connections between them.

    Almost There for the Steam Engine

    leonardo da vinci 3
    Today’s replica of the cart.

    According to today’s specialists, Leonardo da Vinci was even on the edge of discovering steam power at the time, but the absence of energy sources was his largest obstacle in executing his innovations. With his theories, he foresaw industrial mass production by conserving labor and striving for enormous quantities.

    His inventions included rolling mills, which used high-pressure cylinders to create metal sheets and foil. Via massive flywheels, he generated large compressive and tensile forces and then transmitted that power using gears.

    Machines such as drills and cranes, as well as cable winches, the screw machine, and automated printing presses, were all his inventions. Da Vinci anticipated making 60,000 ducats a year from a machine for sharpening needles using leather belts.

    Muscle-Powered Cart

    Da Vinci even designed a self-propelled cart. The gearbox was a set of springs, and the driver must continuously draw and release the springs to provide smooth driving action. Because da Vinci’s cart could only fit one person, the vehicle required a fair amount of physical strength and coordination.

    Claims that Leonardo invented the bicycle have now been debunked. For a long time, the drawing of a rudimentary bicycle from the Codex Atlanticus (1478) was regarded as representing Leonardo’s flash of brilliance.

    Unfortunately, modern research has shown that the sketch was really created in the 20th century and secretly inserted into da Vinci’s notebooks. A sufficient justification for the notion that Leonardo created the bicycle was that the drawing was included in the international printing of a biography of Leonardo in the 1970s without editorial assessment.

    The alarm clock he created and used himself is one example of the strangeness of some of his creations. As water flew from one vessel to another, the filled vessel activated a lever through a gear train, causing Leonardo’s feet to be raised.

    A Fatal Blow to the Perpetual Motion Machine

    Da Vinci's perpetual motion studies.
    Da Vinci’s perpetual motion studies.

    Similarly, Leonardo considered the concept of perpetual motion. He hoped that a machine or device put in motion would continue to run indefinitely and conduct useful labor. Among Leonardo’s many suggestions was the “gravity wheel,” a device in which sheet metal chambers filled with mercury were meant to maintain the wheel’s indefinite spinning.

    Another model wheel he created had balls rolling in grooves to provide asymmetrical torques, causing it to turn.

    In the end, however, he used torque calculations to disprove perpetual motion and suggested that people seeking it instead become goldsmiths. For da Vinci, attempting to maintain constant power generation was like trying to create gold in a lab.

    Leonardo da Vinci’s Dream of Flying

    Fluttering Wings of Birds

    Attempts at flight are now among Leonardo’s most impressive works. During Leonardo’s day, the idea of flying like a bird was not novel, but no one had come closer to making it a reality through their imagination than the brilliant inventor. Even in this area, Leonardo’s ideas were so far ahead of his time that the engineers wouldn’t catch on for another 400 years.

    Concepts like aerostatics and aerodynamics were unfamiliar to Leonardo. His understanding of the phenomenon of lift in the air was rudimentary, primarily focused on his in-depth investigations into air resistance.

    Birds and Bats as Role Models

    He meticulously examined each stage of the bird’s flight, recording them as slightly modified individual images on strips, akin to capturing frames with a movie camera. When assembled, these images seamlessly merged and animated the flight of the bird with a sense of graceful motion on the paper.

    Today's replica of da Vinci's wings.
    Today’s replica of da Vinci’s wings. Credit: Slashvee/Flickr/CC-BY-2.0

    He devoted a quarter of a century to this task. For him, the mechanical wings were the essential component of a flying machine, and bats provided the best inspiration for da Vinci. He used ropes and levers to make his mechanical figures move and animate them, like marionettes. Using lever rods, he created a massive bat wing that a human could flap.

    It wasn’t until 1505 that Leonardo began working on the actualization of a flying machine, following his still fairly analytical wing designs. The issue of propulsion, however, was largely overlooked by him. In his sketches, an “engine” was often nothing more than a block of undefined shape, and he rarely if ever addressed how it really worked. More specifically, he described the structure and workings of the flapping wings.

    An Absence of Driving Power

    To tackle the issue of propelling power, Leonardo proposed having one or more daring pilots to push, pull, and crank with their arms and legs to put the colossal wings in motion.

    He created the first retractable landing gear in aviation history, a structure of stilts 3.3 feet (1 m) high and a stairway by which the flying machine could be reached and carried onboard in order to take off, and a boat that could fly by rowing.

    He turned to the science of aerodynamics after realizing that human muscular strength was inadequate for propulsion and that his contraptions would never fly. The scholar diligently examined the gliding of birds, the falling of leaves, and quantified the aerodynamic characteristics of the air.

    Da Vinci designed the first aerometers to gauge air density, barometers to measure air pressure, and inclinometers to find the angle between an inclined and horizontal surface.

    Parachute and Helicopter

    The invention of the parachute, a crucial tool in contemporary aviation, did not come until after da Vinci had given up on the dream of flying.

    When replicated today, Leonardo’s pyramidal parachute model proved to be effective. In essence, his “rotorcraft,” which consisted of a spiral constructed of two discs positioned above each other and cranked by two men, is comparable to modern helicopters.

    A Glimpse Into Leonardo’s Worldview

    The map of the Tuscan shore in the year 1515 by da Vinci.
    The map of the Tuscan shore in the year 1515 by Leonardo da Vinci.

    In the early spring of 1504, Leonardo began drawing and designing the canal that would connect the Mediterranean to Florence through the Arno River. By exploring the Arno River plain, he hoped to locate more direct pathways for the river.

    Although da Vinci was always on the go due to the river-building project, he utilized his walks to reflect on fundamentals in geology, hydrology, and astronomy. After all, he had to learn about the waters before he could rule them.

    The Codex Leicester, a booklet bound by Leonardo himself, is the product of his observations, drawings, and research on water. In all likelihood, he did not compose the 36 pages in chronological order, but instead sequenced them.

    In this notebook, Leonardo compiled his most seminal insights on the physical universe. Only this notebook of Leonardo’s remains in private hands today. In 1994, Bill Gates paid the approximate equivalent of 31 million US dollars to acquire it at auction.

    Here are just a few examples of the kinds of questions addressed in the Codex Leicester, along with Leonardo’s insightful responses:

    Does the Earth Have a Water Cycle?

    “The waters are thus present beneath the floods within the veins, which originate from the depths of the sea and branch out within the body of the Earth, giving rise to the rivers. These rivers, in turn, continuously draw water from the depths and countless times have given the sea to the sea at the surface and taken the sea from the sea.”

    According to Leonardo, the saltwater must travel down some kind of subterranean water vein to finally reach the mountainous regions. It then makes its way back to the ocean.

    Why Doesn’t the Water Cover the Whole Earth?

    “Enclosed is the sea between the great valleys of the Earth, which serve as its vessel; and the edges of this vessel are the coastlines, and if they were to be removed, the sea would cover the entire Earth. However, since every part of the protruding land is higher than the highest height of the sea, the water cannot flow over them. Instead, it contentedly covers the areas of the Earth that form its basin.”

    How Do Different Stone Shapes Come About?

    “When a river emerges from the mountains, it carries a great number of enormous stones in its bed. As it continues to flow, it carries smaller stones with worn corners, thus reducing the size of the larger stones. Further downstream, it has large pebbles followed by smaller ones, then coarse sand followed by fine sand, then coarse mud followed by fine mud, and so on.

    By the time it reaches the sea, its water is clouded with sand and mud. It deposits the sand along the shores of the sea, followed by the mud. However, it does not remain at the shoreline but, due to its lightness, it returns with the wave, and during calm periods, it sinks and remains on the seabed.”

    Did Rivers Carve Through the Mountains?

    The Chiana Valley and Tuscany in 1502 by Leonardo da Vinci.
    The Chiana Valley and Tuscany in 1502 by Leonardo da Vinci.

    “.. that they, with their meandering course, carried away the high plains enclosed by mountains, and that the mountains were sawed through can be recognized by the layers of rocks, which correspond to each other on both sides of the gorges created by the mentioned river channels.”

    How were the Strait of Gibraltar and the Sinai Mountains Formed?

    “For a long time, the water of the Mediterranean Sea flowed into the Red Sea, eroding the flanks of the Sinai Mountains. This occurred due to the immense, rushing mass of water from numerous rivers that flowed into the Mediterranean, as well as the returning sea. And after, in the west, three thousand miles away from that place where the Mount Calpe was cut through and separated from the Mount Abile, the waters of the Mediterranean began to flow into the western ocean. As the water became shallower, the highest points emerged from the Red Sea, as the water had abandoned its course there.”

    How Do the Atlantic and Mediterranean Oceans Experience High and Low Tides?

    “Ebb and flow are not caused by the moon. This alternation of the sea increasing and decreasing every six hours can be caused by the stagnation of the waters that flow into this sea from the numerous rivers that flow into the Mediterranean Sea. The Mediterranean Sea, in turn, passes the water masses onto the ocean through the Strait of Gibraltar.

    As this ocean expands, it swells and stagnates in the many bays. And since this weight exceeds the force of the approaching water masses, the water again gains momentum in the opposite direction of its approach and mainly pushes against the Strait of Gibraltar, where this water is dammed for some time and also all the water that they have during this time remains and gets anew from the already mentioned rivers.”

    How Does the Ebb and Flow Occur in the Mediterranean and Atlantic?

    “The ebb and flow are not caused by the moon. This alternating pattern, where the sea rises and falls every six hours, can result from the accumulation of water brought into the sea by numerous rivers that flow into the Mediterranean. In turn, the Mediterranean transfers the water masses to the ocean through the Strait of Gibraltar.

    As the ocean expands, it swells in the many bays and becomes dammed. Since this weight exceeds the force of the approaching water masses, the water gains momentum in the opposite direction and pushes primarily against the Strait of Gibraltar. There, the water accumulates for a considerable time, including all the water it receives anew from the aforementioned rivers during this period.”

    Why is the Sky Blue?

    “I assert that the blue in which the air reveals itself is not its inherent color, but it originates from the warm moisture that evaporates into minuscule, imperceptible particles; these particles are struck by the sun’s rays and thereby illuminate themselves beneath the boundless darkness of the fiery realm, which, like a lid, envelops the air from the outside.”

    Why Does the Moon Shine?

    “And if you were to believe that the moon has its own light, then you would be mistaken; and the light you see during its return in the middle of its cycle comes from the fact that it sees our Earth, which receives sunlight, and thus becomes full moon.”

    How Can the Moon Reflect Light?

    “Here it is shown that the moon, which does not possess its own light, would neither be able to receive nor reflect the light it receives from the Sun back to us if it did not have a dense, shiny surface like the surfaces of mirrors and liquids.”

    Naturally, Leonardo was mistaken in some points. Nevertheless, it is surprising how closely he often approached the truth – without a telescope, sediment collector, or other measuring devices. Once again, his most magnificent tool was his mind, capable of drawing such conclusions.

    The Half-Done Genius

    As a representative figure of the intellectual ferment of the 15th century, Leonardo da Vinci exemplified the Quattrocento (“15th Century”). Despite facing many challenges and making many mistakes in his early adulthood, he did it with the enthusiasm of a young man.

    However, as Leonardo got older, he likely came to realize that he, too, was frequently wasting his time trying to uncover the world’s hidden mysteries and turn them into something of practical benefit to humanity.

    Despite spending 20 years at the Sforza Court in Milan, Leonardo never again felt at home. Around 1500, he made his way out of city and continued traveling. He became a combat engineer for Cesare Borgia’s army. He spent some time in Florence, but eventually came back to Milan to work for the French as their royal painter and engineer.

    His time with Pope Leo X in Rome lasted for three years. After both men abandoned him, the French King Francis I picked him up. The royal property of Cloux Manor, not far from the King’s seat in Amboise, was where Leonardo settled in France after being appointed as the King’s architect.

    Here, Leonardo spent his twilight years. He had given up painting but was still working on important matters. His final goal was to open up navigation on the Loire River and its tributaries. Leonardo da Vinci had a stroke on May 2, 1519, and passed on the next day while on the deathbed in Cloux Manor (today known as Clos Lucé). His plans were never materialized.

    This is the second version. Leonardo painted the first between 1483 and 1486. ​​Today it hangs in the Louvre in Paris.
    This is the second version. Leonardo painted the first between 1483 and 1486. ​​Today it hangs in the Louvre in Paris.

    Like many of Leonardo’s ideas, trying to understand him is probably bound to fail. As if gathered by a time traveler, his futuristic knowledge of things had already overwhelmed his fellow humans. Yet, it is impossible not to marvel at the vastness and profundity of his discoveries, inventions, and even his foolish mistakes.

    The barometer, gliders, machine guns, and mechanical alarm clocks were all his creations. It’s unclear, though, how many of his ideas were never put into action.

    What happened to the forts he envisioned and the bridges he drew up? Where are the canals he envisioned, and who operated his spinning mills, drills, and excavators? Had Leonardo da Vinci ever tried to fly himself?

    Unfortunately, almost none of Leonardo’s ideas ever made it beyond his notebooks or weren’t rediscovered and taken seriously until decades later.

    Da Vinci's "The Battle of Anghiari" remained unfinished.
    Da Vinci’s “The Battle of Anghiari” remained unfinished. Credit: Louvre Museum in Paris.

    The “Mona Lisa,” “The Last Supper,” “The Madonna of the Rocks,” “St. John the Baptist,” and “Virgin and Child with Saint Anne” are just a few of the masterpieces that Leonardo left behind. Though he started numerous paintings, he never managed to complete them all. Leonardo spent nearly a decade on the unfinished “Leda and the Swan” artwork.

    The city councils of Florence were his paying customers, and he owed them the “Battle of Anghiari.” Though he received several commissions, Leonardo only completed a handful of paintings. In addition, the bronze he had set aside for a gigantic equestrian statue of Francesco Sforza, whose design had previously gotten him into the Milanese court, was instead used to make cannons, dooming his longest and most laborious sculpture project.

    Art historians and critics argue that Leonardo’s indecisiveness contributed to the global genius’ unfinished works. But in the end, it was the outcome of his desire to make something as flawless as possible.

    Even though many of his machines were feasible and might have been lucrative, Leonardo frequently settled for only hammering out a concept. For him, the pursuit of a problem ended once he discovered its resolution. After he had a rough outline of the evidence and explanation written down, he seldom returned to the same question unless it was necessary to address a different issue.

    In actuality, he was just much ahead of his time. The majority of his plans were never even fully comprehended. Perhaps, though, it is exactly in this imperfection that the charm of his legacy rests.

    A Renaissance Intellectual

    The name Leonardo da Vinci is almost synonymous with the word genius. But his influence on history was largely limited to the development of the field of art. His scientific research saw interest from a limited number of people at the time, and most of his discoveries never materialized.

    Leonardo da Vinci was a typical Renaissance intellectual. He had a great influence on the development of painting, pattern making, and sculpture. In addition to being an innovator in terms of reflecting light and shadow in the picture using new materials and composition, he was also a pioneer in the fields of drawing and perspective of the human anatomy.

    Leonardo was also a great scientist, engineer, and inventor, as we learned from his diaries, which were published a long time after his death.

    The Last Supper, Leonardo Da Vinci.
    The Last Supper, Leonardo Da Vinci, restored, Wikimedia Commons.

    Leonardo da Vinci was born in the town of Vinci, in the Tuscany region of Italy. His father was a notary, and his mother was a maid. At the age of 16, he started working as an apprentice in Florence, in the workshop of the painter Andrea del Verrocchio. Here, his abilities were evident. He was considered a master at the age of 20 and worked in Florence and Milan, where he made some religious paintings such as The Adoration of the Kings, Virgin of the Rocks, and The Last Supper.

    This self-portrait made by Leonardo da Vinci around 1510 had an important place in his life. The artist owed his extraordinary drafting talent to his anatomy studies. He kept detailed notebooks on anatomy during his lifetime, especially while in Milan. These notebooks, containing the artist’s observations, thoughts, drafts, and inventions, were about 13,000 pages. Only 5,000 of these have survived to the present day.

    Portrait of a Man in Red Chalk, 1510. Leonardo da vinci.
    Portrait of a Man in Red Chalk, 1510

    Filled with careful analysis, skepticism, and experience, these notebooks show that Leonardo da Vinci embraced the scientific method much earlier than Galileo Galilei and Isaac Newton. Leonardo was far ahead of his time when he grasped the fields of optics, earth science, hydrodynamics, and astronomy, as well as the principles behind gears, levers, power, and motion.

    Leonardo da Vinci’s Designs

    leonardo da vinci crane
    Leonardo da Vinci’s construction crane.

    Leonardo da Vinci’s double construction cranes were designed for use in quarries. The stones cut from the rock surface get put in one bucket, and when the crane makes a full turn, the other one is filled and the first one gets empty.

    leonardo da vinci model design crank arm

    This model is made according to Leonardo da Vinci’s grooving machine drawing. When the crank arm is turned, the central dowel starts to rotate. With the rotation of the augers on both sides, the cutting tool moves along the central wooden dowel.

    His Unfulfilled Projects

    Between 1485 and 1499, when Leonardo da Vinci worked as an engineer and military architect for the two dukes of Milan, he also provided services for other patrons, such as the famous Cesare Borgia (1475–1507), he found the opportunity to apply some of his theoretical drawings and studies.

    In reality, Leonardo was promising extraordinary engineering projects while offering his services to these people, and he was only mildly talking about his skills in painting.

    Among Leonardo’s notebooks are detailed sketches of many surprising discoveries. Certainly, most of them were never implemented. These drafts include a giant crossbow, various flight machines, a helicopter, a human-like mechanical robot, a diving device, a bicycle, and an alarm clock powered by water-power.

    Since the 19th century, there has been a great interest in Leonardo da Vinci both in academic circles and in the public. In the past few years, some of his discoveries on paper have finally become realities. Leonardo da Vinci’s drawings were surprisingly applicable, although in some cases, they required minor adaptations.

    Only a few of Leonardo da Vinci’s inventions were able to leave the paper and enter human use during his lifetime. However, since there was no patent application in Italy at that time, there were few exact records of how and when the inventions could be used in real life.

    Two known examples are a coil winding machine and a mirror grinding machine. No matter how useful they are, they are not enough to display Leonardo da Vinci’s extraordinary genius and foresight.

    leonardo da vinci design

    Using a spring, Leonardo had envisaged that this vehicle would move like a clock. But there was no place for the driver. The vehicle was designed to go on its own. Like most of Leonardo’s important discoveries, this machine was not produced during the artist’s lifetime.

    leonardo da vinci tank

    This model, made by IBM, was exhibited at the Clos Luce Castle (formerly Manoir du Cloux) in France, the artist’s last home. The top of the da Vinci tank, which was moved by turning the arms, was reinforced with perforated metal plates. Therefore, the soldiers inside the vehicle could still fire outside.

    In 1513, Leonardo da Vinci met François I, King of France, who took over Milan. The king asked Leonardo to build a lion-shaped vending machine. Leonardo made a lion that turned his head and even offered a bunch of orchids when properly cared for.

    The king was so impressed by this invention that he became the protector of Leonardo, and the artist spent the last three years of his life in Amboise, France. Leonardo da Vinci, who is better known for his amazing drawing skills than for his knowledge of science and amazing discoveries, died in this place in peace. 

    Leonardo da Vinci Quotes

    “Learning never exhausts the mind.”

    “Simplicity is the ultimate sophistication.”

    “Time stays long enough for anyone who will use it.”

    “I love those who can smile in trouble, who can gather strength from distress, and grow brave by reflection. ‘Tis the business of little minds to shrink, but they whose heart is firm, and whose conscience approves their conduct, will pursue their principles unto death.”

    “Poor is the pupil who does not surpass his master.”

    “It had long since come to my attention that people of accomplishment rarely sat back and let things happen to them. They went out and happened to things.”

    “I have been impressed with the urgency of doing. Knowing is not enough; we must apply. Being willing is not enough; we must do.”

    “The noblest pleasure is the joy of understanding.”

    “Experience never errs; it is only your judgments that err by promising themselves effects such as are not caused by your experiments.”

    “All our knowledge has its origins in our perceptions.”

    “Although nature commences with reason and ends in experience, it is necessary for us to do the opposite, that is to commence with experience and from this to proceed to investigate the reason.”

    “There are four powers: memory and intellect, desire and covetousness. The two first are mental and the others sensual. The three senses sight, hearing, and smell cannot well be prevented; touch and taste not at all.”

    “Just as food eaten without appetite is a tedious nourishment, so does study without zeal damage the memory by not assimilating what it absorbs.”

    “All knowledge which ends in words will die as quickly as it came to life, with the exception of the written word: which is its mechanical part.”

    “The truth of things is the chief nutriment of superior intellects.”

    “Life well spent is long.”

    “Common sense is that which judges the things given to it by other senses.”

    “Knowledge of the past and of the places of the earth is the ornament and food of the mind of man.”

    “As a well-spent day brings happy sleep, so a life well spent brings happy death.”

    “Men of lofty genius when they are doing the least work are most active.”

  • Johannes Gutenberg: The First Printing Press and Publishing

    Johannes Gutenberg: The First Printing Press and Publishing

    The historical significance of printing cannot be underestimated. The replication of books has made them more affordable and accessible, resulting in greater literacy and the spread of ideas. Johannes Gutenberg, a German goldsmith, invented this innovative technique. 

    Who Was Johannes Gutenberg?

    Little is known about the early years of Johannes Gutenberg’s life except that he was born in Mainz around 1400 and came from a privileged ruling family. He went to university, where he became a bookworm and trained as a goldsmith.

    Around 1420, many families were deported from Mainz after the rebellion of the taxpaying middle class. The Gutenberg family was one of them. Gutenberg then went to Strasbourg and started to work on different things. One of those things was a “secret” that he only told his financial supporters. This secret was probably about the printing press.

    Almost all books were written by clerks at the time, which was a laborious task. As a result, books were scarce and costly, and literacy was confined to the clergy and politicians. Wood printing generated many volumes, but the blocks had to be unearthed one by one for each page. All of this changed with Gutenberg’s latest innovation, the “replaceable/removable letter system.”

    Gutenberg's printing machine replica
    Gutenberg’s printing machine replica

    The removable letter system was a system in which a text was placed in place of individual embossed letters in the frame or matrix. The letters were then inked and printed on paper. The technique was invented in China and Korea in the 11th century, but it never became widespread, probably because of the large number of written Chinese and Korean characters.

    Johannes Gutenberg invented his system with this technique. The method was simple and effective. First, he carved holes in hardened steel, and the holes were in the form of embossed letters. Through these holes, he would strike the letters on copper. He then placed the “negative” copper into his hand-held mold, which is his invention, and poured the molten metal into it, allowing him to make as many copies of the letters as he wanted. The metal used by Gutenberg was an alloy of lead, tin, and antimony, which melted easily and solidified rapidly in the mold. The alloy is still used today in printing on letterpress and on hot metal.

    Gutenberg Press

    A page from the Gutenberg Bible. Gutenberg made 180 copies of the Bible. The books were a sensation when they first exhibited at the trade fair in Frankfurt in 1454.
    A page from the Gutenberg Bible. Gutenberg made 180 copies of the Bible. The books were a sensation when they first exhibited at the trade fair in Frankfurt in 1454.

    In the 1440s, while still in Strasbourg, Gutenberg set out to experiment with a new part of the printing system: The Press. The screw press used by winemakers inspired Gutenberg’s press. The inked, striped text was placed face up on a level surface, covered with paper, and then moved beneath a very heavy stone; the screw was then rotated, and the paper was placed into printing letters. The text could be replicated as this procedure was repeated.

    Gutenberg also created oil-based ink that was more durable than the water-based ink that was commonly used at the time. He thought that when he put all of these ideas together, his invention would change the world. 

    Gutenberg and The First Printed Bible

    johannes gutenberg
    Johannes Gutenberg.

    In 1448, Gutenberg returns to Mainz. He borrows money from a wealthy investor named Johann Fust (about 1400-1466) to open a printing shop. Knowing that the church is his main client, Gutenberg decides to publish the Bible. After an attempt to print some other texts, such as Latin grammar, Gutenberg began to study the Bible in 1452. The low price and high-quality printing of the Bible ensured the success of Gutenberg’s new technology, and the technology quickly spread throughout Europe. Millions of books were going to be published in 1500. Thus, Gutenberg realized the first media revolution.

    Unfortunately, however, Johann Fust wanted his money back and accused Gutenberg of embezzlement. Gutenberg is told to hand over the printing equipment to Fust for the loan he borrowed. After that, Fust became a successful printer, and Gutenberg opened a small printing shop near Bamberg. Subsequently, in 1465, Gutenberg moved to a smaller city, where he was eventually appreciated for his invention and was awarded a pension. Three years later, he died blind and poor.

    Roller Printing Machine

    Although Gutenberg’s innovation revolutionized history in a short amount of time, printing books remained a tedious process. A large number of employees were required, and only a hundred pages per hour could be produced. With the creation of the cast-iron printing press and the introduction of steam power in the nineteenth century, printing speeds of up to a thousand pages per hour were achieved. Richard March Hoe, an American inventor, made another significant contribution to the history of printing in 1843 (1812–1886).

  • Guglielmo Marconi: The Invention of the Radio Communication System

    Guglielmo Marconi: The Invention of the Radio Communication System

    The history of the invention of the radio is not fully enlightened. The honor of this important invention has been claimed in the names of dozens of leading scientists. Among those, the Italian Guglielmo Marconi was one of the most successful and important personalities. Guglielmo Marconi invented the radio and made it available to everyone.

    Who Was Guglielmo Marconi?

    Guglielmo Marconi was born in Bologna, Italy, as the son of an Italian father and an Irish mother. He was interested in science at an early age, especially in the field of electricity. In late 1894, he learned about the experiments of the German physicist Heinrich Hertz (1857-1894). In the late 1880s, Hertz demonstrated the existence of radio waves.

    Hertz produced radio waves by sending upward and downward alternating currents rapidly shifting from a vertical antenna, and he was able to monitor these waves for up to 20 meters. Marconi read an article about the recent demonstration by British physicist Oliver Lodge (1851-1940). Using Hertz waves, Lodge had sent wireless messages in Morse code. At that time, Morse’s telegraphic messages could only be sent by wire and using electric pulses. The possibility of using wireless telegrams impressed Marconi.

    Marconi’s major purpose in conducting his own tests was to make the wireless telegraph a technology utilized in daily life. Marconi set up a laboratory in his house’s attic, gathering the required instruments. Soon, he was sending Morse code across greater distances and receiving responses: first inside his room, then to the end of the hallway, and then out into the countryside. Marconi delivered a message around 2 kilometers distant in the summer of 1895, and he patented the technique in 1896. He chose to relocate to England when the Italian government denied his financial help request. 

    Relationship between Guglielmo Marconi and Titanic

    After a series of impressive demonstrations of the invention, Marconi received financial support from the Postal Administration, which was then responsible for the telegraph service in England. In the same year, he founded the Wireless Telegraph & Signal Company. Over the next few years, he was able to send messages over long distances, especially ship-to-ship and ship-to-shore.

    In 1900, Guglielmo Marconi decided to expand the transmission range further. His new goal was to cross the Atlantic Ocean. In 1901, three short radio signals symbolizing the letter “S” in the Morse code were transmitted from Poldhu, in Cornwall, England, to St. John’s City, in Newfoundland (then an English colony, now part of Canada).

    This successful transmission to St. John’s echoed across the world. A year later, when it was claimed that the transmission was fraudulent, he performed another experiment. This time, he was able to receive signals from Cornwall, which was more than 3200 kilometers away from his ship, close to the Canadian coast.

    In the following years, Marconi launched the first radio transmission system. Marconi’s name was heard once more in 1912 when the British ship RMS Titanic crashed into an iceberg. A Marconi-radio operator on the sinking ship was able to send signals and ask for help from the surrounding ships.

    The Inventor of the Radio

    In the 1920s, Marconi began experimenting with high-frequency radio waves. These “short waves” could be focused by a curved reflector behind a transmitter, similar to parabolic receivers used to receive satellite broadcasts. Since the waves did not form in a beam and spread in all directions, this new arrangement made the radio much more effective and energy-efficient.

    At that time, other radio operators like Marconi were able to transmit not only the Morse code but also speeches, music, and audio signals. In 1931, Marconi conducted experiments with radio waves (microwaves) of higher frequencies and shorter wavelengths. A year later, he established a microwave radiotelephone system that broadcast in a certain direction between the Vatican and the Pope’s summer residence. The infrastructure of the current communication system is based on similar microwaves.

    Marconi did not actually invent the radio, but in many ways, he contributed to the development of the radio. His efforts have transformed the radio from a complex lab instrument to an everyday device with commercial success and made our world a little smaller. In 1929, he was awarded the Nobel Prize in Physics for his contributions to the field of wireless telegraphy. In 1930, he was elected President of the Royal Italian Academy.

    Lee de Forest’s Audion tube

    In the early 1900s, radio communication was only feasible by wireless telegraphy, that is, Morse code messages based on radio wave pulses of varying durations known as “dots” and “dashes.” This changed with the advent of audio transmission, and regular broadcasts started in 1920. Audion, created in 1906 by US inventor Lee de Forest, was one of the most crucial technologies for the development of audio broadcasting.

    The earliest example of an electron tube was the Audion. It offered several application options, which aided in the creation of new electrical gadgets. Audion was involved in the development of entirely electronic “oscillators” capable of producing radio waves of any frequency in the area of radio and television transmission. Electron tubes were employed to increase the power of radios and TVs from the 1920s until the 1960s. Transistors, which were created in 1947 and used less energy, took their place.

    Quotes

    “In the new era, thought itself will be transmitted by radio.”

    “The coming of the wireless era will make war impossible, because it will make war ridiculous.”

    “Have I done the world good, or have I added a menace?”

    “The mystery of life is certainly the most persistent problem ever placed before the thought of man. … The inability of science to solve it is absolute. This would be truly frightening were it not for faith.”

    “Every day sees humanity more victorious in the struggle with space and time.”

  • George Eastman: The Kodak Era and Popular Photography

    George Eastman: The Kodak Era and Popular Photography

    George Eastman and the legacy he left for the world. Only a few professionals and enthusiastic amateurs were interested in photography in its first fifty years. It was expensive, time-consuming, cumbersome, and demanding expertise. All these adversities changed in 1888 when the American inventor George Eastman introduced a machine that was both cheap and convenient.

    Who Was George Eastman?

    George Eastman was born on a small farm in New York. When he was 5, his family moved to Rochester. George lost his father when he was 8 years old, and his family suffered a lot during that time. Eventually, George was forced to give up his education at the age of 13 and start to work. He was eager to learn and learned many things through his efforts.

    Eastman’s interest in photography started when he was planning a trip abroad while working as a bank clerk at the age of 24. When a colleague told him to record his trip, Eastman bought a camera. The machine consisted of a large, coarse box and was attached to a heavy tripod. Inside the box were individual glass plates, which were placed in large plate slots and covered with photosensitive emulsion instead of film. The plates had to be prepared for outdoor shots in a portable tent that served as a darkroom.

    In 1878, George Eastman learned about “dry plates,” invented in 1871 by British photographer Richard Leach Maddox. The emulsion was coated on the plates with gelatin. These plates could be stored and used at any time. Thus, the majority of the equipment Eastman purchased was unnecessarily large. While Eastman continued to work at the bank, he devoted all his free time to finding the most competent method of producing dry plates in series.

    In 1880, he founded the Eastman Dry Plate Co. In 1881, he began to produce and sell dry plates and soon decided to use a lighter, more flexible material instead of glass. In 1884, he considered rolling the flexible plate. Accordingly, the machine would have a rolling slot instead of a plate slot. The first device, known as a “detective camera” using a film roll, appeared in 1885. The roll was made of paper, and this method did not produce the desired result because the fibers in the paper were visible in printing.

    George Eastman: “You press the button, we do the rest”

    1440px Film strip
    35 mm roll films took over the market since 1925, when it was used for still photography. This continued until the advent of digital machines in the 1990s. Image: Bart Everson.

    In the meantime, other researchers were working on flexible and dry plates too. Some researchers have been experimenting with nitrocellulose, also known as celluloid. Eastman launched celluloid film in 1889.

    Eastman’s genius move showed that he had to expand the photography market to succeed. The way to do this was to make photography, in his own words, “as convenient as the pencil.” He had to develop a new, smaller, and reasonably priced machine. In 1888, the first Kodak machine was introduced and soon achieved great success.

    The camera is equipped with a roll that can store up to 100 photos. Once the camera owner took the photos, all he had to do was send the camera to Eastman’s company, wait for the photos to come out, and take it back with a new film. The main factor in Kodak’s success has been taking photography to a level that everyone can reach. Eastman’s short statement suited the situation: “You press the button, we do the rest.”

    Later, George Eastman renamed the corporation Eastman Kodak and dominated the market by offering “cheap photography.” He was never married and never had children. He assisted universities, hospitals, and dentistry clinics as a significant benefactor. He had been suffering from a deteriorating bone ailment for the last two years. He took his own life in 1932 by shooting himself in the heart. “My work is done, why wait?” he said in his suicide note.

    Brownie Camera

    Kodak’s first camera with widespread demand had a retail price of $25. That was half the amount Eastman paid for his first camera. But it was still a high price for amateur photographers. In 1900, Eastman Kodak introduced a new, very cheap camera solution: the Brownie. Between 1900 and 1980, Eastman Kodak produced and sold 99 different Brownie models.

    The first Brownie Machine was a cardboard box with a roll holder, a roll of film, and a lens. Outside the box, there was a shutter and a winder. The world’s cheapest camera was sold for $1 (approximately $30 today). Thus, the “snapshot” era began. It was able to capture the moments without requiring any preparation.

    Quotes

    “Light makes photography. Embrace light. Admire it. Love it. But above all, know light. Know it for all you are worth, and you will know the key to photography.”

    “What we do during our working hours determines what we have; what we do in our leisure hours determines what we are.”

    “You push the button, we do the rest.”

    “If a man has wealth, he has to make a choice, because there is the money heaping up. He can keep it together in a bunch, and then leave it for others to administer after he is dead. Or he can get it into action and have fun, while he is still alive. I prefer getting it into action and adapting it to human needs, and making the plan work.”

    “I used to think that music was like lace upon a garment, nice to have but not necessary. I have come to believe that music is absolutely essential to our community life.”

    “I don’t believe in men waiting until they are ready to die before using any of their money for helpful purposes.”

    References

    1. Ackerman, Carl W. (1930). George Eastman: Founder of Kodak and the Photography Business. Beard Books. ISBN 1-893-12299-9.
    2. Brayer, Elizabeth (1996). George Eastman: A Biography. Baltimore: Johns Hopkins University Press. ISBN 0801852633.
    3. “The Wizard of Photography”PBS.
    4. Collins, Douglas (1990). The Story of Kodak (1st ed.). New York: Harry N. Abrams, Inc. ISBN 9780810912229.
  • Rita Levi-Montalcini: The Discovery of the Nerve Growth Factor

    Rita Levi-Montalcini: The Discovery of the Nerve Growth Factor

    Who was Rita Levi-Montalcini? A fertilized egg divides into two, then four, then eight, and countless other cells. While it does not show any features at first, it performs a miraculous thing by transforming into a skin cell, a liver cell, and a series of other cells that make up our bodies. The ability to control some of these activities in research on cellular growth and the development of unique characteristics in each tissue is one of the greatest developments in the history of medicine and has paved the way for many miraculous developments.

    Rita Levi-Montalcini and Mussolini’s bigotry

    Rita Levi-Montalcini: The discovery of the Nerve Growth Factor

    Studies in developmental embryology in the 1940s led to the discovery of nerve growth factor, followed by epidermal factor and many other growth factors, as well as cytokines, including erythropoietin, which stimulate the proliferation of red blood cells (erythrocytes). Rita Levi-Montalcini, a clever and pleasant woman, was from a highly distinguished family of intellectuals, artists, architects, and mathematicians. Despite having an interest in writing since childhood, she became a physician. But her passion for discovering things never stopped. She expresses her passion for discovery in these words:

    In 1936, Mussolini published the declaration “Manifesto per la Difesa della Razza,” signed by 10 Italian “scientists.” Following the declaration, a series of laws were enacted that banned the academic and professional careers of non-Ari Italian citizens. After working for a short time at a neurological institute I visited in Brussels, I returned to Turin with my family. Meanwhile, Belgium was on the verge of occupation by the German army in the spring of 1940.

    We had two options in front of us: We would either move to America or stay here, regardless of the practices of the Aryan world. My family chose the second option. After this decision, I decided to establish a research laboratory in my bedroom at home. In this decision, Viktor Hamburger’s 1934 article on “The effect of the destruction of peripheral areas in chicken embryos” played a major role.

    The bombing of Turin by the Anglo-American Air Force in 1941 forced us to leave and move to a village. I also re-established my small laboratory in the village house there and continued my work. In the autumn of 1943, the Italian army attacked Italy, forcing us to leave the village of Piedmont where we took refuge, and move to Florence. We lived there in secret until the war was over.

    During our stay in Florence, I was in contact with many of my close friends and brave supporters of the “Partito di Azione” party. In August 1944, Anglo-American forces were trying to expel German occupants from Florence. At that time I was hired as a physician at the Anglo-American forces’ headquarters; I was working in a camp where refugees were brought to Florence from the areas where the war continued violently. When I was working as a nurse and doctor in this camp, where infectious epidemics and typhus swarmed, and there were a lot of deaths, every day I shared their pain and fear of death.

    The war in Italy ended in May 1945. I returned to Turin with my family and resumed my academic post at the university. In the autumn of 1947, Viktor Hamburger invited me to work together to repeat our previous experiments on chicken embryos, which changed the course of my life.

    Rita Levi-Montalcini, “Autobiography”, “The Nobel Prizes, Ed. Wilhelm Odelberg / Stockholm: Nobel Foundation 1987

    Experiments on chicken, and mouse

    When Levi-Montalcini was working on chicken embryos, she placed the mouse tumor cells on the cell wall of the chicken and saw that the nerve tissues of the chicken developed and multiplied remarkably. Nerve elements continued to reproduce in mouse tumors as if they were out of control and also began to form kidneys, thyroid glands, spleens, and other tissues from the nervous system of the chicken. As a result of a series of rigorous experiments, Levi-Montalcini and her assistants found that the mouse tumor circulated in the blood, causing the secretion of a small protein (peptide) that acts as a hormone, activating the formation and proliferation of target tissue (nerve cells). Levi-Montalcini called this peptide a “nerve growth factor”.

    Her friend Dr. Stanley Cohen discovered the “epidermal growth factor” at about the same time. These growth-promoting hormones were discovered in highly irrelevant sites, namely cancerous tumors, snake venom, and salivary glands. Since the mouse nerve growth factor was also effective in chickens, there were many inter-species activities. Because biologically active peptide sequences tend to pass through the evolutionary process without being destroyed.

    When a newborn mouse was given an antibody that influenced nerve growth factors in the saliva and the growth factor was inhibited, the development of the sympathetic nervous system stopped. Nerve cells, particularly those in the early stages of differentiation, are extremely sensitive to the nerve growth factor’s growth-promoting and controlling activities. Although there is activity in adult mouse tissues, it is not as intense as in newborn mouse tissues.

    The description of cytokines

    Growth factors are peptide hormones that affect cell division or differentiation by binding to receptors on the cell surfaces of target tissues and initiating signal transduction events. Many growth factors are variable factors that influence cell division in a wide variety of cell types. Some affect only certain cells.

    Cytokines are the most unique group of growth factors. Primarily secreted by the white blood cells, cytokines stimulate both the secretory and cellular immune responses together with phagocytic cells (white blood cells that absorb pathogens, uric acid crystals, and many other harmful agents). Cytokines released by lymphocytes are called “lymphokines,” and cytokines released by monocytes or macrophages are called “monokines.”

    A large family of cytokines is produced by various body cells. Many lymphokines are also known as “interleukin” (IL) because they are secreted by leukocytes and can affect the cellular responses of leukocytes. Interleukins are growth factors that specifically target cells of hematopoietic origin (which develop from bone marrow stem cells). Currently, the number of interleukins with 22 distinct functions identified is increasing.

    • Epidermal Growth Factor (EGF)
    • Platelet-Induced Growth Factor (PDGF)
    • Fibroblast Growth Factors (FGFs)
    • Beta Transforming Growth Factor (TGFs-β)
    • Alpha Transforming Growth Factor (TGF-α)
    • Erythropoietin (Epo)
    • Insulin-like Growth Factor-1 (IGF-1)
    • Insulin-like Growth Factor-2 (IGF-2)
    • Interleukin-1 (IL-1)
    • Interleukin-2 (IL-2)
    • Interleukin-6 (IL-6)
    • Interleukin-8 (IL-8)
    • Tumor Necrosis Factor-Alpha (TNF-α)
    • Tumor Necrosis Factor-Beta (TNF- β)
    • Interferon-gamma (IFN-γ)
    • Colony Stimulating Factors (CSFs)
    • Brain Induced Neurotrophic Factor (BDNF)

    Understanding the mechanisms of cytokines and growth factors on cell division sheds light on cancer treatment methods known as uncontrolled cell division. After chemotherapy, growth factors and cytokines are increasingly used in people with anemia, such as activating red blood cell proliferation. Thus, Rita Levi-Montalcini and Stanley Cohen discovered the first growth factor in 1952, the nerve growth factor.

    Rita Levi-Montalcini quotes

    “Above all, don’t fear difficult moments. The best comes from them.”

    “I tell young people: Do not think of yourself, think of others. Think of the future that awaits you, think about what you can do and do not fear anything.”

    “The body does whatever it wants. I am not my body; I am my mind.”

    “Find first peace within yourself. Don’t eat too much. Keep your brain active. Love.”

    “I should thank Mussolini for having declared me to be of an inferior race. This led me to the joy of working, not any more unfortunately, in university institutes but in a bedroom.”

    “My experience in childhood and adolescence of the subordinate role played by the female in a society run entirely by men had convinced me that I was not cut out to be a wife.”

    “Progress depends on our brain. The most important part of our brain, that which is neocortical, must be used to help others and not just to make discoveries.”

    “At 100, I have a mind that is superior – thanks to experience – than when I was 20.”

    “At 20, I realized that I could not possibly adjust to a feminine role as conceived by my father and asked him permission to engage in a professional career. In eight months I filled my gaps in Latin, Greek and mathematics, graduated from high school, and entered medical school in Turin.”

    “If I had not been discriminated against or had not suffered persecution, I would never have received the Nobel Prize.”

    “You’ve been thinking about something without willing to for a long time…Then, all of a sudden, the problem is opened to you in a flash and you suddenly see the answer.”


    Sources:

    1. Levi-Montalcini, Rita, In Praise of Imperfection: My Life and Work.(Elogio dell’imperfezione) Basic Books, New York, 1988.
    2. Mastella: sì al procedimento su Storace”la Repubblica. 17 October 2007.
    3. “Dispetto alla Montalcini al seggio”. La Repubblica. 14 April 2008.
    4. “The Nobel Prize in Physiology or Medicine 1986”. The Nobel Foundation.
    5. Yount, Lisa (1996). Twentieth Century Women Scientists. New York: Facts on File. ISBN 0-8160-3173-8.
  • Paul Ehrlich: Magic Bullet, Theories, Chemotherapy and More

    Paul Ehrlich: Magic Bullet, Theories, Chemotherapy and More

    Paul Ehrlich was a tremendous scientist. In 2001, members of the Nobel Foundation reviewed Nobel Prize winners to decide which one had brought the greatest benefit to humanity in the last century. Rolf Luft, the former chairman of the medicine and physiology award committee and the most senior member of the Nobel committee, placed Paul Ehrlich (1854–1915) at the top of the list, especially because of his creativity as a theorist. Ehrlich’s conceptual and practical contributions to the field of science were so great that it was a dilemma to show only one of them on the list. All these contributions prove his genius and talent. Here is a list of his unusual ideas:

    Paul Ehrlich and his contributions to science

    • To put forward the concept and the term “Magic Bullets.”
    • Conceptualization of “cell membrane receptors.”
    • Finding the first syphilis treatment.
    •  Laying the foundations of immunology.
    •  Coined the term chemotherapy.
    • Establishing hematology (blood science).
    • Treatment of diphtheria using antitoxins.

    He was a man of ideas, a great theorist rather than a great experimenter.

    At the beginning of the 20th century, there were only a few chemical drugs that effectively cured diseases. Aspirin and morphine were painkillers, and it was always known that foxglove strengthened the heart muscles; amyl nitrate provided relief by dilating coronary vessels during heart spasms. Colchicine was used in the treatment of acute gout; iron was known to provide strength to the body; cassia was used to treat diseases; quinine was used to treat malaria; and mercury was used to treat syphilis and hair loss.

    All of these treatments were derived from herbal remedies. There were many medicines prescribed by physicians, but most of these medicines had no real cure.

    paul ehrlich magic bullets
    Paul Ehrlich’s magic bullets

    The theory of microbes is used to create immunity to diseases (by increasing antibodies in the body with microorganisms that do not harm the human body). This move resulted in true therapeutic drugs and brought the science of treatment to the point where it is today. Paul Ehrlich was the first person to start this change because of his knowledge of bacteriology and immunology and his close ties to the German chemical industry.

    All of Paul Ehrlich’s contributions to science were based on the concept of “selective toxicity,” in which chemical structures permit dissimilar biological activities. He was surprised by the specificity of antigen-antibody reactions and the selectivity of tissues stained with methylene blue and other aniline dyes. He was convinced that the certainty of biological activity was closely related to the chemical structure; what convinced him was that a molecule, like the key sitting in the hole, had receptor areas on the stained cell membrane. He did conceptual studies to figure out what these areas were, looking for targets in pathogenic microbes and making “Magic Bullets,” which are chemicals that kill the microbes without hurting people.

    Treatment of Syphilis

    While working on syphilis, he found that the arsenic compounds used to destroy the syphilis-causing organism treponema pallidum were both highly toxic and ineffective. He used chemotherapy to synthesize and test over 600 arsenic atoms to find the one with the best anti-treponemal activity. The number 606 showed strong activity against this organism, and he called this arsenic composition “salvarsan.” The drug was modified and renamed “neosalvarsan” and later “neoarsphenamine.” Despite being extremely toxic and requiring injection, it was the first effective syphilis treatment until 1910.

    Neosalvarsan, although not a drug that has the effect of magic bullets, is considered a beginning in this field. In 1927, employees of IG Farben, a powerful cartel in the German chemical industry, discovered that prontosil red, one of the azo dyes used in fabric dyeing, treated rats that had streptococci (I.G. Farben was also the company that produced toxic Zyklon B gas, used in Nazi concentration camps).

    Research conducted at the Pasteur Institute has confirmed this finding, and it has been found that the prontosil sulfonamide stops the growth of organisms, although it does not eliminate streptococci. This bacteriostatic activity alerts the patient’s immune system, allowing the body to get rid of the bacteria. Thus, a “miracle drug” was found that detected and destroyed the target bacteria without damaging normal cells, just like the magic bullets from the “first chemical synthetic drugs.” In addition to its antibacterial effects, Prontosil is also characterized by the fact that it was synthesized in 1907 and no one owns the patent, making it accessible everywhere.

    Quotes

    “Success in research needs four Gs: Glück, Geduld, Geschick und Geld. Luck, patience, skill and money.”

    “The first rule of intelligent tinkering is to save all the parts.”

    “The cell concept… is the axis around which the whole of the modern science of life revolves.”

  • Alfred Wegener: Pioneer of Continental Drift Theory and Pangea

    Alfred Wegener: Pioneer of Continental Drift Theory and Pangea

    Alfred Wegener (Alfred Lothar Wegener) was recognized for two very different successes in his life: Arctic climate research and the theory of continental drift. However, according to him, these two initiatives were very reasonable efforts due to his passionate interest in climate studies. Wegener was born on November 1, 1880, in Berlin. During his education, he focused primarily on astronomy, then on meteorology and climate science.

    In 1905, he became a meteorological observer at the Urania Observatory near Berlin; in 1909, he started teaching at the University of Marburg and taught astronomy and atmospheric physics. In 1924, Wegener received a long-desired professorship offer from the University of Graz, Austria. Until that time, he had already attracted some attention and raised some doubts with his theory of how the great land masses of the Earth came about.

    Alfred Wegener’s Continental Drift Theory

    This ice house, built by Alfred Wegener, stayed in use after his death.
    This ice house, built by Alfred Wegener, stayed in use after his death.

    He started his first research in Greenland in 1906, when he was invited as a climate scientist and glaciologist to a Danish expedition led by Ludvig Mylius-Erichsen. In 1912, he again went to Greenland on a Danish expedition, during which time he became one of the first people to cross Greenland from east to west with his dog sled. These expeditions boosted Wegener’s reputation in Europe, especially in Denmark and Germany.

    Alfred Wegener consulted with the leading climate scientist Wladimir Köppen while planning the Greenland expeditions. Meanwhile, Köppen was working on the classification of the world’s climates. In 1913, he married Köppen’s daughter, Else. Köppen was more experienced at the time, so he mentored Wegener. However, the two soon began working together in research on paleoclimate, which is based on geological and paleontological evidence, such as coal deposits, salt deposits, plant and animal fossils, and glaciers. The idea of the continental drift theory emerged here.

    Pangaea or Pangea
    Pangaea or Pangea

    Alfred Wegener first found some identical fossils on both sides of the ocean. Moreover, he saw the same phenomenon in the geological formations that started in Africa and continued in South America. Geologists were already aware of these cases. They put forward the theory that plants and animals migrated between continents through land bridges that are not available now. But Wegener was developing an alternative theory. He compared the shores of every continent and realized how they fit against each other like jigsaw puzzle pieces. He stated that these geological features formed an ongoing pattern. From this point on, he began to focus on the idea of Continental Drift and tirelessly looked for geological and paleontological evidence to test his hypothesis.

    If we are to believe Wegener’s hypothesis, we must forget everything that has been learned in the last 70 years and start all over again.

    R. T. Chamberlin, University of Chicago, 1928,

    In 1915, he published “The Origin of Continents and Oceans.” In this book, he argued that all the continents were interconnected into a massive land mass, which he called “Pangaea,” meaning “Urkontinent” or “All-Lands” in Greek. Pangaea gradually disintegrated, and the continents shifted to their current positions. The Continental Drift Theory was taking shape.

    Arguments Against Wegener’s Theory

    Alfred Wegener’s book sparked a storm of controversy among geologists over the flaws in the theory. The quarrels reached a global dimension after the book was translated into English. Two international conferences were held to discuss the continental drift theory, one in London in 1923 and the other in New York in 1926. Wegener did not attend any of these conferences.

    Alfred Wegener

    Geologists at the London conference found haunting geological deficiencies in Wegener’s supporting evidence. They stated that the geological mapping, which supported the claim that the continents were interconnected, was insufficient. All those who stood against the theory rejected the proposal that the tides and the Earth’s rotation could provide the force to move the continents. The English geologist Philip Lake was among the critics of Wegener and outspokenly said, “He is deaf to every argument.” The distinguished mathematician and geophysicist Harold Jeffreys said, “It is out of the question,” stating that there could be no force strong enough to move the continents.

    The North American Conference was particularly unpleasant. Because the concept of uniformity had occupied a strong place in the indoctrination of American geologists, the philosophy that was created by James Hutton and others at the end of the 18th century states that the existing natural laws and processes are always present and functioning unchanged. The continental drift theory was concluded not to be an ongoing process, and the argument was rejected. But only a few people found the idea of land bridges irrational and questioned the lack of evidence. In short, a new paradigm was desperately needed. 

    Mockery of the Continental Drift Theory

    The Origin of Continents and Oceans book had not been accepted for a long time.
    The Origin of Continents and Oceans book had not been accepted for a long time.

    The main factor preventing Wegener’s theory from being supported was the lack of information on the great force driving the continents across the earth’s crust. However, several geophysicists have come up with the idea that a driving force might be produced that can move fixed continents over time. In the fourth edition of his book, Wegener embraced the idea that convection currents in the earth’s crust could move the continents.

    As the distinguished geologists openly rejected Alfred Wegener’s theory, other geologists also comfortably criticized his idea. The idea of continental drift had become the subject of sarcastic jokes: ‘Half of a fossil was found in America and the other half in Europe.’ Many geologists looked at Wegener as if he were crazy. Still, few geologists and biologists liked the idea of moving continents because it had the potential to answer many unanswered questions, yet there was still a lack of evidence for the movement.

    Although Wegener was disappointed at being rejected, he was still approaching every criticism with resistance and determination, assuming that people saw only part of the picture. He wrote in the 4th edition of his book: “Scientists still do not appear to understand sufficiently that all earth sciences must contribute evidence toward unveiling the state of our planet in earlier times, and that the truth of the matter can only be reached by combining all this evidence.” He never stopped compiling new findings and evidence from many different disciplines to answer criticism later in his book. By the fourth edition, Wegener’s book was really thick.

    The Greenland Budget: $125,000

    Alfred Wegener and Rasmus Villumsen prepare for the journey on November 1, 1930.
    Alfred Wegener and Rasmus Villumsen prepare for the journey on November 1, 1930.

    The theory of continental drift remained idle for forty years after the American conference, that is, for thirty-odd years after the death of Alfred Wegener. Until the mapping of the earth’s sea beds in the 1960s, using new tools and substantial government funding, the theory gained momentum with the encouragement of the Cold War. These new efforts demonstrated the seabed’s expansion and eventually produced a lot of evidence supporting concepts such as convection currents and plate tectonics in the earth’s crust.

    Alfred Wegener turned his attention to Greenland’s climate in the last two years of his life. A German research fund committee set up to fund valuable researchers in the challenging economy of the 1920s supported Wegener for a modest project to explore the Greenland climate. Due to Greenland’s impact on the European climate and its location on possible air routes between Europe and North America, this support was an important matter in those days.

    Wegener then saw an unexpected opportunity. He proposed to the committee to expand the aid to a much larger project that would include glacial investigations as well as observing the climate with three stations to be installed in Greenland. Glacier surveys would include measurements of the ice accumulation rate. His proposal required 500,000 German marks (45,000 marks or 125,000 USD at 1929 exchange rates). This was a huge amount at the time. The committee accepted the proposal rapidly, and it was an indication of its great respect for Wegener.

    Alfred Wegener’s Death

    The Eismitte was dug into ice during Alfred Wegener’s expedition (July 1930–August 1931).
    The Eismitte was dug into the ice during Alfred Wegener’s expedition (July 1930–August 1931).

    In the summer of 1929, Wegener took his lead assistant on his expedition to select a location on the west coast of Greenland suitable for transporting tools and materials to the upper glaciers. In the spring of 1930, the recruited ship with 20 men from Germany arrived with two propeller sleds, tons of food, and tools.

    They experienced a six-week delay in unloading the cargo due to the late breaking of the ice in the Kamarujuk Fjord. They worked throughout the summer to compensate for the lost time and to establish the manned station they named Eismitte (Mid-Ice) in the middle of Greenland. Bad weather and hardware malfunctions did not allow them to fully prepare the central station. The two men dug a multi-room ice cave in Eismitte and settled here to wait for the preparations to be completed. Some essential equipment, such as a prefabricated hut and a shortwave radio, never arrived at Eismitte, as well as food and fuel, which were in short supply.

    When the winter storms started in September Wegener wanted to bring food and equipment to Eismitte, 250 miles away, with dog sleds. It was a desperate move. They completed the journey in 40 days, which usually lasts 14 days, due to delays caused by the storm and disagreements with the Eskimos who helped them. Most of the Eskimos refused to cover the entire distance and returned to the west coast. A day after reaching Eismitte, Wegener and the only remaining Eskimo, Rasmus Willumsen, set out to return to the west coast. It was the first day of November 1930, which was Wegener’s 50th birthday. They never reached the shore. The following summer, a search team discovered Wegener’s body in a tomb marked by skis. It was estimated that he died of heart failure, due to excessive effort. Willumsen was never found.

    Wegener was best known for his work in the Arctic when he was healthy, but today he is remembered for his comprehensive understanding of the moving continents. As many important details were missing, critics of Wegener could never fully embrace the holistic view of the theory of continental drift. However, the movement of the continents has turned into plate tectonics today, and it has become widely accepted.

    Alfred Wegener at a Glance

    Who was Alfred Wegener, and what was his most significant contribution to science?

    Alfred Wegener, a German meteorologist, geophysicist, and polar researcher, made a substantial impact on the scientific community with his proposal of the continental drift theory. According to his theory, the continents were once united as a supercontinent known as Pangaea and have since gradually separated over time.

    What is the theory of continental drift proposed by Alfred Wegener?

    Alfred Wegener’s theory of continental drift posits that the Earth’s landmasses were once interconnected as a massive supercontinent known as Pangaea. Gradually, these landmasses have moved apart, eventually reaching their present-day locations.

    What evidence did Wegener use to support the theory of continental drift?

    Wegener provided multiple pieces of evidence to bolster the continental drift theory. These included the interlocking puzzle-like fit of continents, the correlation of geological features across different land masses, the presence of similar fossils on distinct continents, and the distribution of specific climate indicators in ancient rock formations.

    How was Wegener’s theory of continental drift received by the scientific community during his time?

    At first, Wegener encountered skepticism and resistance from the scientific community regarding his theory of continental drift. Numerous geologists and scientists during his era struggled to embrace the notion of continents shifting across the Earth’s surface.

    What is Pangaea, and how did Wegener propose its existence?

    Pangaea, the supercontinent theorized by Wegener to have existed roughly 300 million years ago, was proposed based on the concept that continents appeared to interlock like puzzle pieces. The geological evidence, coastal similarities, and fossil findings provided substantial support for the notion that these continents were once interconnected as part of a larger landmass.


    Bibliography:

    1. Wegener, Alfred (1 July 1912). “Die Entstehung der Kontinente”Geologische Rundschau (in German). 3 (4): 276–292. Bibcode:1912GeoRu…3..276W. doi:10.1007/BF02202896. ISSN 1432-1149. S2CID 129316588.
    2. Wegener, Alfred (1911). Thermodynamik der Atmosphäre [Thermodynamics of the Atmosphere] (in German). Leipzig: Verlag Von Johann Ambrosius Barth. (in German)
    3. Alexander du Toit (1944). “Tertiary Mammals and Continental Drift”. American Journal of Science242 (3): 145-63. Bibcode:1944AmJS..242..145D. doi:10.2475/ajs.242.3.145.
  • William Harvey: Revolutionized Biomedical and Medicine Sciences

    William Harvey: Revolutionized Biomedical and Medicine Sciences

    William Harvey was a fascinating individual. It is striking to think that a single published work has changed the future of biomedical sciences and medicine more than any other publication in the past fifteen centuries. This work is Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus, published in 1628 by William Harvey. This thin book put an end to the physiology and medicine dogmas of Galenus of Bergama, which had been affecting the Western world since the beginning.

    Who Was William Harvey?

    William Harvey
    William Harvey (1578-1657)

    William Harvey was from a wealthy Folkestone family. He was the eldest of the seven brothers, of which five would later become traders in London. He got his bachelor’s degree from Cambridge University in 1597 and went on a long learning journey in France, Germany, and Italy. In 1602, he received a doctorate in medicine and philosophy from the University of Padova, where he attended the anatomy course of Fabricius ab Aquapendente (also known as Girolamo Fabrizio), who discovered the valves of the vessels. He returned to London immediately after graduation and was elected a member of the Royal College of Physicians in 1604.

    Harvey had remarkable fame during his lifetime. He became the private physician of King James I and his son, Charles I. In addition to his intensive clinical practice, he became a physician at one of the oldest hospitals in London, St. Bartholomew’s. He was extremely patient, persistent, and careful as a scientist. It took 25 years for his studies to bear fruit. He once complained to a friend that his medical profession was damaged due to his publications on blood circulation and his colleagues’ being jealous of his reputation, which called him “crackbrained.”

    He was aware that he was making a mark in the history of medicine and did his best to pursue his fame. He left part of his fortune to the Royal College of Physicians and gave Cambridge’s Caius College his birth house and the land around it.

    William Harvey once said in On the Formation of Animals, 1651, that nature should be investigated; the paths it showed us should be boldly walked, because only by moving from lower to higher levels can we penetrate the very heart of the mystery of nature by consulting our appropriate senses.

    Blood and heart

    William Harvey performs an experiment to prove his hypothesis of blood circulation to King Charles I of England.
    William Harvey performs an experiment to prove his hypothesis of blood circulation to King Charles I of England. (Rue Des Archives/album)

    According to the teaching of Galen, blood was drawn from the liver and lung, flowing to the right side of the heart, and after passing through the ventricle, the tidal movement began between the left ventricle and the arteries. At the beginning of the 17th century, it was argued that the heart was the source of heat and that the lungs served to cool the blood. It was assumed that diastole (the rhythmic expansion of the heart) combines blood and air, and the warmed and revitalized blood enters the circulatory system. The blood being darker in the veins and lighter in the arteries was attributed to the different functions of the two vessels, such as the ability to feed tissues and maintain the vital spirit.

    Harvey’s observations completely changed these ideas. He discovered that the left ventricle of the heart sends blood continuously and unidirectionally from the lungs to the main arteries and tissues, and that the blood from the right ventricle, through the last veins, is sent from here to the lungs. Harvey had come to the conclusion that the amount of blood coming out of the veins should enter the arteries for the systems to work properly. For this to happen, the outside blood had to move cyclically from the arteries to the veins. He thought that the same principle should apply to the circulation in the lungs; blood should flow from the right ventricle to the left ventricle through the lungs.

    CDN WELL V 18138 min
    Ernest Board’s painting depicts William Harvey explaining his blood circulation theory to his tutelary Charles I.

    The observation of the heartbeat being synchronized with the pulse resulted in the faulty idea that the heart and arteries may contract and relax simultaneously. It was believed that the heartbeat felt by the hand was the enlargement of the heart. Harvey was able to argue for this idea by directly observing the chest walls of the animals. The reason a heartbeat was felt by hand was due to the contraction of the heart when sending the blood out and the enlargement of the ribs when relaxing. So, the pulse in the arteries was not due to the diastole (enlargement), but to the systole (contraction).

    William Harvey’s work, de Motu Cordis

    A drawing from William Harvey’s de Motu Cordis, 1628, depicting forearm surgery.
    A drawing from William Harvey’s de Motu Cordis, 1628, depicting forearm surgery.

    To express his thesis about blood circulation in his work, de Motu Cordis, Harvey resorted to quantitative reasoning, which was a fairly new approach. He did not believe that the source of a large amount of blood, which was constantly entering the heart from veins, could only be the food consumed. He also noticed that the amount of blood flowing in the blood vessels was well above the amount needed to feed the various parts of the body. This simple reasoning resulted in the idea that a fixed amount of blood moves “cyclically” in the body. This contribution was truly revolutionary, and it would take many years for general acceptance.

    But Harvey not only made discoveries but also created the experimental method that would be pursued in biology and medicine experiments hundreds of years later. The study always starts by asking questions (there were more than twenty such questions in the first part of de Motu Cordis), some of which are intended to politely demonstrate the absurdity of the current views, and the answers should be very clear.

    These are followed by questions that form the basis of the experiment. At the heart of his method was vivisection—the practice of performing operations on live animals. This experimental technique opened all the doors for Harvey. The observation made at a certain point in time (i.e., the dissection of a dead animal) was not sufficient to answer some functional questions. Thus, continuous and sequential observations of live animals were necessary. The attachment, removal, and opening of the vessels of the body parts were the means of understanding and revealing normal physiology.

    William Harvey’s curious mind

    Exercitationes de Generatione Animalium (Exercises on the Generation of Animals) was published by Harvey in 1651.
    Exercitationes de Generatione Animalium (Exercises on the Generation of Animals) was published by Harvey in 1651.

    From the first days of his professional career, Harvey realized that every new breed he worked with brought him new insight. The animal species he studied were diverse. In the later years of his life, when he switched to studying embryogenesis in animals, his highly curious mind was in the most open state possible. He had always had the maxim to be objective, but he could not help but admire the creation and the creator behind it. He was interested in embryology and its earliest stages of development. What happens first? What follows next? Such thoughts stand out in Harvey’s 1961 book, Exercitationes de Generatione Animalium.

    In addition to his intense curiosity toward medicine, William Harvey was a revolutionary who pursued refined and disciplined thought processes while conducting biology experiments. The result was a fundamentally new understanding of how the human body works. He showed his students how to ask the right questions, deal with them, and answer them.

    William Harvey quotes

    “Very many maintain that all we know is still infinitely less than all that still remains unknown.”

    “I profess to learn and to teach anatomy not from books but from dissections, not from the tenets of Philosophers but from the fabric of Nature.”

    “The heart is the household divinity which, discharging its function, nourishes, cherishes, quickens the whole body, and is indeed the foundation of life, the source of all action.”

    “Civilization is only a series of victories against nature.”

    “Nature is a volume of which God is the author.”

    “Moderate labor of the body conduces to the preservation of health, and cares many initial diseases.”

    “I have often wondered and even laughed at those who fancied that everything had been so consummately and absolutely investigated by an Aristotle or a Galen or some other mighty name, that nothing could by any possibility be added to their knowledge.”

    “Only by understanding the wisdom of natural foods and their effects on the body, shall we attain mastery of disease and pain, which shall enable us to relieve the burden of mankind.”


    Bibliography:

    1. Power, D’Arcy (1897). William Harvey: Masters of Medicine. T. Fisher Unwin. ISBN 978-1-4179-6578-6.
    2. Mitchell, Silas Weir (1907). Some Memoranda in Regard to William Harvey, M.D.
    3. Munk, William (1878). The Roll of the Royal College of Physicians of London, Vol. I (2nd ed.). London. pp. 124–146.
    4. William Harvey info from the (US) National Health Museum
    5. Rapson, Helen (1982). The Circulation of the Blood. London: Frederick Muller.